Find out more about Alfaxan® Multidose
And how it works
Alfaxan® Multidose is formulated with the active ingredient alfaxalone in an aqueous solution with a pH of 6.5-7 and is registered for the induction and maintenance of anaesthesia in dogs and cats and the induction of anaesthesia in pet rabbits. Download SPC.
Alfaxalone is a neuroactive steroid molecule, with central effects. Despite being an analogue of progesterone, alfaxalone does not bind to sex hormone, glucocorticoid, or mineralocorticoid receptors69.
Features
Can your induction agent do all of this?
Smooth induction53, 54
Stress-free recovery 48, 50, 51
Minimal distruption to cardio-pulmonary function or vascular system parameters 50, 51
Wide safety margin50, 51
Compatible with routine premedicant regimes42, 43, 53, 54
Can be used confidently on consecutive days45, 46, 47
Safety
Alfaxan® Multidose has a very wide safety margin.
Therapeutic index
Acute tolerance to overdose of Alfaxan® Multidose at 5 times the registered dose (i.e. 25 mg/kg) in cats and 10 times the registered dose (i.e. 20 mg/kg) in dogs was demonstrated where animals required only ventilation to allow recovery with no residual effect. 50, 51, 52
Repeated Dosing
Repeated overdosing with Alfaxan® Multidose - 5 times the registered dose every 48 hours over a six day period caused no adverse effects. 45, 46
Extra-vascular safety
Alfaxan® Multidose does not cause tissue irritation should accidental peri-vascular or subcutaneous injection occur. 49, 52
Paediatric
Alfaxan® Multidose is licensed for use in puppies and kittens from 12 weeks of age. 71
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C-Section
Alfaxan® Multidose can be used prior to canine caesarean section. 37, 71
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Sighthounds43
Alfaxan® Multidose is approved for use in greyhounds, salukis, whippets etc.
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Vets have experienced the benefits of Alfaxan’s safety margin and minimal impact on cardiorespiratory parameters in their canine and feline patients for many years. 26-36,37-39, 42-46, 48-51, 53, 54
How does Alfaxan work
Alfaxalone induces anaesthesia through activity at the gamma amino butyric acid sub-type A receptor (GABAA) present on cells in the Central Nervous System (CNS). GABA is a major inhibitory neurotransmitter in the CNS. Alfaxalone enhances the effects of GABA at the GABAA receptors resulting in opening of channels into the cells and an influx of chloride ions. This causes hyperpolarisation of the cells and inhibition of neural impulse transmission. 62, 68
History
Steroids were first recognised to have anaesthetic properties in the 1940s 66, 67. Numerous investigations and iterations of steroid molecular modification have occurred over time in the attempt to create useful formulations of neurosteroid molecules. 63, 64, 65
The first commercially manufactured formulation of neurosteroids was widely used through the 1970s and 1980s in both human and veterinary anaesthesia. Neurosteroid anaesthesia was recognised for its excellent anaesthetic properties and minimal effects on cardiovascular function. 60, 61
In the 1990s it was found that alfaxalone could be solubilised in aqueous solution by first complexing it to large sugar molecules known as cyclodextrins. 56, 57, 58
